目前对于Mirtoselect® 的应用研究主要集中在血管健康及眼部健康(视网膜水平的眼部保健)领域,但流行病学研究、动物模型研究以及最新的人体临床研究表明花色苷具备更加广泛的临床应用前景,包括了改善记忆力,胃肠道健康以及心血管健康。
尤其,最新的初步研究表明Mirtoselect® 对初级代谢症候群和葡萄糖代谢具有一定的改善作用。这进一步为Mirtoselect® 在除眼部健康1-5以外的其它领域的应用提供了支持。
Krikorian R. et al., J Agric Food Chem. 2010 Apr 14;58(7):3996-4000.
Karlsen A., J. Nutr. 2007, 137, 1951-1954.
Mink, P. J. Am. J. Clin. Nutr. 2007, 85, 895-909.
Campbell, F. M., et al., In: Obesity facts 2012, 5 (s1) p198.
Hoggard N. et al., Journal of Nutritional Science, 2013, vol. 2, e22, page 1 of 9.

通过促进血液循环,Mirtoselect® 能够增加眼部的氧分血液供给,使眼部维持正常的功能性泪液分泌。此外,其清除自由基的特性有效抵御了氧化压力,后者是引起干眼症及眼部不适的主要影响因素。Mirtoselect® 是唯一一个其特性经过人体灵床和动物试验验证的欧洲越橘提取物。
最新又发表了一篇 Mirtoselect® 在保护眼部健康,尤其是针对干眼症,的临床数据。这项新的随机双盲安慰剂-对照研究9进一步为 Mirtoselect® 的安全有效性提供了数据支撑,同时表明保持适量的泪液水平及良好的眼表卫生能够极大地改善眼部不适及视觉障碍。截至目前,Mirtoselect® 是唯一经人体临床证实具备改善干眼症症状的欧洲越橘提取物(Vaccinium myrtillus L.)。
Riva A. et al, European Review for Medical and Pharmacological Sciences, 2017;21: 2518-2525.
- Krikorian R. et al., J Agric Food Chem. 2010 Apr 14;58(7):3996-4000.
- Karlsen A., J. Nutr. 2007, 137, 1951-1954.
- Mink, P. J. Am. J. Clin. Nutr. 2007, 85, 895-909.
- Campbell, F. M., et al. In: Obesity facts 2012, 5 (s1) p198.
- Hoggard N. et al., Journal of Nutritional Science, 2013, vol. 2, e22, page 1 of 9.
- Kim E.S., J. Korean Ophthalmology Soc., 2008;49(10):1629-1633.
- Kajimoto S. et al., J. New Rem. Clin., 2000, Vol.49 N.1, 72-79.
- Mazzolani F. et al., Minerva Oftalmol 2017 June;59(2)_38-41.
- Riva A. et al, European Review for Medical and Pharmacological Sciences, 2017;21: 2518-2525.
欧洲越橘 vs. 蓝莓
欧洲越橘(Vaccinium myrtillus L.)是一种遍布在欧洲中北部丘陵荒野和下层丛林中的小型灌木。在北欧森林中野生生长,与蓝莓不同,蓝莓是三种美洲本土品种(V. corymbosum, V. ashei 和 V. angustifolium)的杂交品种,且为人工种植。蓝莓的果实成簇,而欧洲越橘的果实为单生或双生。
此外,两种浆果在果实形态大小及外观颜色也存在明显差异,欧洲越橘果实较小且颜色较深。
果肉颜色部分,欧洲越橘果肉是蓝色/深紫色,蓝莓呈绿色。欧洲越橘果实更坚硬,果汁含量低,较蓝莓而言更便于运输。




- Mazza G., Miniati E., CRC Press (1993).
- Andersen O.M. and M. Jordheim M., CRC Press, Boca Raton, FL (2006), pp. 471–530.
- Kumi Yoshida, Mihoko Mori and Tadao Kondo., Nat. Prod. Rep., 2009, 26, 884-915, Review.
- Prior R.L., Cao G., Martin A., Sofic E., McEwen J., O’Brien C., Lischner N., Elhenfeldt M, Kalt W., Krewer G., Mainland C.M., J. Agric. Food Chem. 46, 2686 (1998).
- Brenneisen R., Steinegger E., Pharm. Acta Helv. 56, 180 (1981).
- Brenneisen R., Steinegger E., Pharm. Acta Helv. 56, 341 (1981).
- L. Jaakola, K. Määttä, A.M. Pirttilä, R. Törrönen, S. Kärenlampi and A. Hohtola, Plant Physiology 130 (2) (2002), pp. 729–739.
- Kaisu R., Määttä-Riihinen KR, Kamal-Eldin A, Mattila PH, González-Paramás AM, Törrönen AR., J. Agric. Food Chem. 2004, 52, 4477-4486
- Internal Report: 01/08/LRA-00
Vaccinium myrtillus
许多红色的水果中含有大量有益健康的抗氧化物,尤其是花色苷类化合物,能够作为预防多种疾病的辅助天然膳食补充剂。
众多食物中均天然含有花色苷——如红酒、多种谷物和茎叶蔬菜(茄子、甘蓝、豆子、洋葱、萝卜)——但以色泽丰富的水果,如欧洲越橘,含量最为丰富1。此外, Prior 等2 已报道欧洲越橘(Vaccinium myrtillus L.)中花色苷的含量高于其他种类的浆果。 (Vaccinium myrtillus L.)是一种可食用的生长于欧洲中北部野生小灌木丛中3-7。
在 450 种8越桔属(Vaccinium)植物中,欧洲越橘(Vaccinium myrtillus L.)从中世纪开始就有药用记载,其果实被推荐用于改善机体各种不适状态,从16世纪开始这种植物已在所有主流草药专著中被系统地提及。
Nutrient U.S. Department of Agriculture, A.R.S., USDA Database for the Flavonoid Content of Selected Foods, Release 3.0 2011.
Prior R.L. et al., Antioxidant Capacity As Influenced by Total Phenolic and Anthocyanin Content, Maturity, and Variety of Vaccinium Species, J. Agric. Food Chem. 46, 2686 (1998).
Tutin T.G., Diapensiaceae to Myoporaceae, Flora Europaea Vol. 3, Cambridge University Press, Cambridge, 1972, pp 12-13.
Hutchinson J., British Wild Flowers Vol. 1, David and Charles, Newton Abbot, 1972, p 226.
Benigni R., Piante Medicinali – Chimica, farmacologia e terapia, Vol. II, Inverni della Beffa, Milano, 1962, pp 951-958.
Hegi G., Illustrierte Flora von Mittel Europa, Band 5/3 Teil, C. Hanser Verlag, Munchen, 1927 (Reprint 1966), pp 1667-1681.
Upton R. American Herbal Pharmacopoeia and Therapeutic Compendium – Bilberry Fruit 2001.
Mabberly D.J., The Plant-Book II Ed., Cambridge University Press, 1997.

与其他浆果不同,欧洲越橘产量十分有限:它的果实并非成簇结生,以单果居多,少量双果,再加之其植株数量十分有限,因此十分珍贵。

欧洲越橘果实与其他浆果相比更加绵软多汁,因此在运输过程中十分容易造成挤压损伤,对运输要求严格。
欧洲越橘无法人工种植,需从野外森林人工采摘获得。由于欧洲越橘果实组织遭受损伤后会激发产生花色苷降解程序,对其化学稳定性造成不利影响,因此一般先对其进行冷冻后再处理。
欧洲越橘果实中的不同类别的化学组分已被分离出来,尤其是其中的花色苷类化合物(也被称为花青素糖苷),已在科学文献中被广为记载。
20世纪70年代早期,Indena 发明了标准化欧洲越橘提取物产品,其在血管健康方面的有益作用已得到超过60篇科学文献的广泛证实,其中至少30篇为经同行评议的对照或双盲研究。9
Morazzoni P., Vaccinium myrtillus L., Fitoterapia 1996, 67, 3-29.

- Nutrient U.S. Department of Agriculture, A.R.S., USDA Database for the Flavonoid Content of Selected Foods, Release 3.0 2011.
- Prior R.L. et al., Antioxidant Capacity As Influenced by Total Phenolic and Anthocyanin Content, Maturity, and Variety of Vaccinium Species, J. Agric. Food Chem. 46, 2686 (1998).
- Tutin T.G., Diapensiaceae to Myoporaceae, Flora Europaea Vol. 3, Cambridge University Press, Cambridge, 1972, pp 12-13.
- Hutchinson J., British Wild Flowers Vol. 1, David and Charles, Newton Abbot, 1972, p 226.
- Benigni R., Piante Medicinali – Chimica, farmacologia e terapia, Vol. II, Inverni della Beffa, Milano, 1962, pp 951-958.
- Hegi G., Illustrierte Flora von Mittel Europa, Band 5/3 Teil, C. Hanser Verlag, Munchen, 1927 (Reprint 1966), pp 1667-1681.
- Upton R. American Herbal Pharmacopoeia and Therapeutic Compendium – Bilberry Fruit 2001.
- Mabberly D.J., The Plant-Book II Ed., Cambridge University Press, 1997.
- Morazzoni P., Vaccinium myrtillus L., Fitoterapia 1996, 67, 3-29.
Bilberry and Indena
新鲜采摘的欧洲越橘(Vaccinium myrtillus L.)果实在-35℃的通风系统中进行冷冻,完成后进行机械自动化处理,根据果实的大小进行分拣(去除小的果实),称量(以去除其中可能含有的小石块),并去除枝叶。
利用Niagara系统挑拣出可能混入的红豆越橘(Vaccinium vitis-idaea)并弃用。通过传送带将越橘果实输送至高点后自由落下,感应器检测下落中的果实的颜色是否超出设定的颜色范围。此外,在对干净的越橘果实进行包装或在大盒中进行暂时存贮前需对机器挑拣出的果实进行人工复检 .

标准的欧洲越橘提取物具备特有的经HPLC分析的“指纹“图谱。1,2
纯正的欧洲越橘提取物含有≥36%花色苷,以及各种丰富的非花色苷成分,
后者对其活性功效的发挥亦至关重要。1,2
Gizzi C. et al., Bilberry extracts are not created equal: the role of non anthocyanin fraction. Discovering the “dark side of the force” in a preliminary study, European Review for Medical and Pharmacological Sciences, 2016 Jun; 20(11):2418-24.
Motohashi N., Occurrences, Structure, Biosynthesis and Health Benefits based on their evidences of medicinal phytochemicals in vegetables and fruits – Volume 5 – 2016.
Gizzi C. et al., Bilberry extracts are not created equal: the role of non anthocyanin fraction. Discovering the “dark side of the force” in a preliminary study, European Review for Medical and Pharmacological Sciences, 2016 Jun; 20(11):2418-24.
Motohashi N., Occurrences, Structure, Biosynthesis and Health Benefits based on their evidences of medicinal phytochemicals in vegetables and fruits – Volume 5 – 2016.

Indena为如何鉴别欧洲越橘花色苷和花青素开发了出明确的不可争议的分析方法。这个基于HPLC的方法定义了标准化欧洲越橘提取物花色苷含量为36%(相当于UV方法25%花青素含量)。已成为西方国家多部药典的法定标准品。3-7
Indena生产的欧洲越橘提取物是市面上受研究最为深入和广泛的提取物。
目前对 Mirtoselect® 的应用研究主要集中在血管健康和眼部(视网膜)健康领域,但动物及人体模型研究初步表明花色苷具备更广泛的临床应用前景,如提高记忆力,改善胃肠道健康、心血管健康,对代谢综合征和体重进行辅助管理。
Mirtoselect® 在临床应用上表现出了高度的稳定性,尤其是在眼部健康方面。其稳定的活性功效与产品原料的精挑细选,贮存和批次间的高度一致性有密切的关系。
同时人体模型研究表明 Mirtoselect® 具备良好的耐受性。
Mirtoselect® 是一种深紫色粉末,能够用于各种膳食补充剂中,推荐剂量:160-320 mg/天。
Cassinese C., New liquid chromatography method with ultraviolet detection for analysis of anthocyanins and anthocyanidins in Vaccinium myrtillus fruit dry extracts and commercial preparations., J. AOAC Int. 2007, 90 (4), 911-919.
Baj E. et al, Qualitative and quantitative evaluation of Vaccinium myrtillus anthocyanins by HRGC and HPLC., J. Chromatogr. 1983, 279, 365-372.
European Pharmacopoeia 6th Ed. Suppl. 6.2 Fresh bilberry Fruit Dry Extract Refined and Standardised, 3745-3747.
FU Mirtillo Nero Estratto Secco Purificato e Titolato XI Ed. Suppl. 1, 2005, 1469-1472.
USP 31–NF 26 – Second Supplement Powdered Bilberry Extract (Identification and Assay).
Indena在20世纪70年代早期即开始研究欧洲越橘提取物。这些年来,我们对这种珍贵的小蓝果优质生物功效活性愈发感兴趣,而如今,Mirtoselect® 不仅是市面上仅有的研究最为广泛的欧洲越橘提取物,且其已成为市场的金标准。Indena为健康行业,为客户以及终端消费者带去行业内几乎无人可媲美的高品质产品; Mirtoselect® 是Indena领导植物提取物行业发展以及Indena在创新及高品质植物活性成分具备专业化水平的最佳典范。
Mirtoselect®的里程碑历程:
- Gizzi C. et al., Bilberry extracts are not created equal: the role of non anthocyanin fraction. Discovering the “dark side of the force” in a preliminary study, European Review for Medical and Pharmacological Sciences, 2016 Jun; 20(11):2418-24.
- Motohashi N., Occurrences, Structure, Biosynthesis and Health Benefits based on their evidences of medicinal phytochemicals in vegetables and fruits – Volume 5 – 2016.
- Cassinese C., New liquid chromatography method with ultraviolet detection for analysis of anthocyanins and anthocyanidins in Vaccinium myrtillus fruit dry extracts and commercial preparations., J. AOAC Int. 2007, 90 (4), 911-919.
- Baj E. et al, Qualitative and quantitative evaluation of Vaccinium myrtillus anthocyanins by HRGC and HPLC., J. Chromatogr. 1983, 279, 365-372.
- European Pharmacopoeia 6th Ed. Suppl. 6.2 Fresh bilberry Fruit Dry Extract Refined and Standardised, 3745-3747.
- FU Mirtillo Nero Estratto Secco Purificato e Titolato XI Ed. Suppl. 1, 2005, 1469-1472.
- USP 31–NF 26 – Second Supplement Powdered Bilberry Extract (Identification and Assay).
- C. Artaria, R. Pace, G. Maramaldi, G. Appendino., “DIFFERENT BRANDS OF BILBERRY EXTRACT – A comparison of selected components”, NUTRAfoods 2007 6(4) 13-18
- European Pharmacopoeia 6th Edition – Supplement 6.2 – «Fresh bilberry Fruit Dry Extract Refined and Standardised».
- FU XI Ed, 1st Suppl. 2005, «Mirtillo Nero Estratto Secco Purificato e Titolato». 30 USP 31–NF 26 – Second Supplement, «Powdered Bilberry Extract » (Identification and Assay).
European Pharmacopoeia 6th Edition – Supplement 6.2 – «Fresh bilberry Fruit Dry Extract Refined and Standardised»
FU XI Ed, 1st Suppl. 2005, «Mirtillo Nero Estratto Secco Purificato e Titolato»
USP 31–NF 26 – Second Supplement , «Powdered Bilberry Extract» (Identification and Assay)