Anthocyanins inhibition of cyclic nucleotide phosphodiesterases

Antioxidant activity | Inhibition of cyclic nucleotide phosphodiesterases | Antiplatelet activity | Interaction with collagen, phospholipids and proteoglycans | Effect on arteriolar vasomotion | Chemoprevention | Cohort studies

The anthocyanins cyanidin, delphinidin and malvidin 3-O-glucosides and their aglycones are reported to inhibit phosphodiesterase (PDE) isoforms from different sources as retina, choroid, large vessels and platelets. The compounds were more active on retinal than on platelet PDEs and in particular on the retinal calmodulin stimulated enzymes. IC50 of malvidin and delphinidin 3-O-glucosides on calmodulin stimulated enzymes ranged from 5.4 to 35.6 µM. Anthocyanins appeared more active than isobutylmethylxanthine used as reference.^(1-3)

1. Ferretti C., Magistretti M.J., Robotti A., Ghi P., Genazzani E., Pharmacol. Res. Commun. 20, Suppl. 2, 150 (1988).
2. Ferretti C., Blengio M., Malandrino S., Pifferi G., XIth International Symposium on Medicinal Chemistry, Jerusalem, Israel, September 2-7 (1990).
3. Pifferi G, Malandrino S., Morazzoni P., Ferretti C., XVIth International Conference of the Groupe Polyphenols, Lisbon, July 13-16, 1992 - Polyphenols Actualities 8, 60 (1992).

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