Effect on arteriolar vasomotion of anthocyanins

Antioxidant activity | Inhibition of cyclic nucleotide phosphodiesterases | Antiplatelet activity | Interaction with collagen, phospholipids and proteoglycans | Effect on arteriolar vasomotion | Chemoprevention | Cohort studies


The arteriolar vasomotion, a rhythmic variation of diameter of arterioles in microvascular network, influences the microvascular mechanism which regulates the formation of interstitial fluid. Colantuoni et al.⁽¹⁾ studied the effects of Bilberry 36% extract on arteriolar vasomotion in two experimental models: the cheek pouch of anaesthetized hamster and the skin fold window preparation (muscular type) of un-anaesthetized hamster. Bilberry 36% extract (5-10 mg/kg i.v.) induced vasomotion suppressed by anaesthetic in cheek pouch arterioles and terminal arterioles, and increased vasomotion frequency in the skeletal muscle arteriolar network. These findings indicate that the Bilberry extract may prevent or control interstitial fluid formation and contribute to control the blood flow redistribution in the microvascular network.

1. Colantuoni A., Bertuglia S., Magistretti M. J., Donato L., "Effects of Vaccinium Myrtillus anthocyanosides on arterial vasomotion", Arzneim. Forsch. 41, 905 (1991).

BACK